ABSTRACT
Objective To investigate the effects of proprioceptive training on lumbar disc herniation (LDH). Methods 50 patients with LDH were divided into experimental group (n=25) and control group (n=25). Both groups received physiotherapy and core stability exer-cise, and the experimental group received proprioceptive training with BIODEX Balanced System in addition. They were assessed with the Visual Analogous Scale (VAS) of pain, Oswestry Disability Index (ODI), and posture stability and limits of stability of BIODEX Balanced System. The incidence of relapse was followed up in a year. Results The scores of VAS, ODI, posture stability and limits of stability im-proved in both groups after treatment (P<0.05), and the ODI, posture stability and limits of stability improved more in the experimental group than in the control group (P<0.05). There were 5 cases relapsed in the control group, and 2 cases in the experimental group. Conclu-sion The proprioceptive training may further improve the function of lower back, and motor control in patients with LDH, and prevent the re-lapse.
ABSTRACT
@#Objective To explore the application of Brief ICF Core Sets for Chinese Stroke Patients in rehabilitation assessment for patients with stroke. Methods 180 patients with stroke accepted routine rehabilitation for 2 months, and were assessed with ICF core set, Barthel Index (BI), Functional Comprehensive Assessment (FCA) and WHO Disability Assessment Schedule (WHODAS II) before, 2 and 6 months after treatment. Results The score of BI, FCA and WHODAS II correlated with that of ICF core sets (P<0.05). Conclusion ICF core sets can be used as a tool to assess the function of patients with stroke.
ABSTRACT
@#Objective To explore the application of Brief ICF Core Sets for Chinese Stroke Patients in rehabilitation assessment for patients with stroke. Methods 180 patients with stroke accepted routine rehabilitation for 2 months, and were assessed with ICF core set, Barthel Index (BI), Functional Comprehensive Assessment (FCA) and WHO Disability Assessment Schedule (WHODAS II) before, 2 and 6 months after treatment. Results The score of BI, FCA and WHODAS II correlated with that of ICF core sets (P<0.05). Conclusion ICF core sets can be used as a tool to assess the function of patients with stroke.
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Objective To study the effects of psychological rehabilitation in the treatment of paraplegic patients with spinal cord injury (SCI).Methods A hundred paraplegic spinal fracture survivors were divided into a research group and a control group with 50 cases in each.Systematic rehabilitation was given to the patients in the control group,while this was combined with individualized psychological rehabilitation protocols for the patients in the research group.The daily treatment lasted 10 weeks,6 days a week.All of the patients were assessed with the Barthel index (BI),a functional independence measure (FIM),the Hamilton depression scale (HAMD) and the Hamilton anxiety scale (HAMA) pre-treatment and post-treatment.Results Before the intervention there was no significant difference between the 2 groups in any of the assessments.After ten weeks the average BI,FIM,HAMD and HAMA results in the research group were significantly better than those pre-treatment and also significantly better than those in the control group.Conclusions Psychological rehabilitation can distinctly improve the functioning and psychological state of paraplegic patients after SCI.
ABSTRACT
In order to investigate the neuroprotective effects of cyclin-dependent kinase-5 (cdk-5) inhibition in mice with Niemann-Pick disease type C (NPC) (npc(-/-)), recombinant adeno-associated virus (rAAV) carrying the small interfering RNA (siRNA) specific for cdk-5 gene was injected into 3-day-old npc(-/-) mice intracerebroventricularly. The rAAV-GFP-injected age-matched npc(-/-) mice and non-surgery age-matched npc(-/-) mice were employed as controls (n=6-10/group). From the 4th to 8th week after the treatment, mice were weighed, and evaluated for limb motor activity by using the coat hanger test once a week. Eight-week-old npc(-/-) mice were sacrificed by decapitation, and brains were quickly dissected and halved sagittally. Immunohistochemistry, Western blotting, and HE staining were used to evaluate the neuropathology in npc(-/-) mice. The results showed that rAAV-cdk-5-siRNA-GFP significantly reduced the number of axonal spheroids, delayed the death of Purkinje neurons, ameliorated motor defects in npc(-/-) mice, and significantly attenuated the hyperphosphorylation of tau proteins. These data suggested that inhibition of cdk-5 activity has neuroprotective effect on neurons in NPC mice.